Inspired by a traditional African village, separate rondavel "huts" house the luxury guest rooms.The uniquely crafted bedroom units maximize the use of local materials in order to blend with their surroundings. The grass capping of the roofs comes from locally occurring (but outside of the Serengeti Park) savannah grass. The buildings' stone facings utilized the stone shale that was found on the site and is common throughout the Serengeti area.

Each bedroom has its own self-contained private shower-room and toilet as well as its own balcony with views across the Serengeti plains.

The architecture and design of Serengeti Serena Lodge makes maximum use of locally available, naturally occurring, materials and indigenous designs. Walking to the dining room and bar area of the Lodge, guests pass through open corridors with rich African carvings and high roofs.

The lodge's cuisine is focused on its use of fresh food that is sumptuously prepared and cooked in front of the guests. The full-service lounge and bar serves fresh fruit juices, soft drinks, tea and coffee, cocktails, wines, spirits and liqueurs.